PT-141 (Libido/Sex drive) 10mg – Apoxar

PT-141 (Libido/Sex drive) 10mg – Apoxar

PT-141 (Libido/Sex drive) 10mg – Apoxar, also known as Bremelanotide, is a synthetic peptide used primarily for improving libido and treating sexual dysfunction in both men and women. It is sold under brand names like Vyleesi and is also available in research-grade forms like Apoxar PT-141 10mg. PT-141 works by targeting melanocortin receptors in the brain, which influence sexual arousal and desire.

Mechanism of Action

• Melanocortin Receptor Agonist:
  • PT-141 binds to MC3R and MC4R (melanocortin receptors) in the central nervous system, bypassing hormonal pathways to directly stimulate sexual arousal.
  • Unlike PDE-5 inhibitors (e.g., Viagra), PT-141 does not act on blood flow but on the neurological pathways that trigger sexual desire.

Key Benefits

1. Improved Libido:
   • Increases sexual arousal in both men and women.
   • Effective for hypoactive sexual desire disorder (HSDD) in premenopausal women.
2. Erectile Dysfunction (ED) Treatment:
   • Helps men achieve and maintain erections, especially those with ED caused by psychological factors.
3. Enhanced Sexual Pleasure:
   • Many users report heightened sensitivity and overall sexual satisfaction.
4. Alternative to PDE-5 Inhibitors:
   • Ideal for individuals who cannot use drugs like Sildenafil (Viagra) or Tadalafil (Cialis).

Dosage and Administration

• Standard Dosage:
  • 1–2 mg subcutaneously (SC) injected about 30–60 minutes before sexual activity.
  • Dosage can be adjusted based on individual tolerance and effectiveness, with a maximum of 2 mg per day.
• Reconstitution:
  • If provided as a lyophilized powder (e.g., Apoxar PT-141 10mg), reconstitute with bacteriostatic water (typically 1–2 mL) and store in a refrigerator.

Effects Timeline

• Onset: Effects are typically felt within 30–60 minutes of administration.
• Peak: Sexual arousal peaks around 2–4 hours after injection.
• Duration: Effects can last up to 8–12 hours, with residual benefits for up to 24 hours.

Side Effects

1. Common:
   • Nausea (most reported side effect, dose-dependent).
   • Flushing or warmth in the face.
   • Mild headache.
   • Temporary fatigue or dizziness.
2. Less Common:
   • Increased blood pressure (monitor in individuals with hypertension).
   • Darkened skin pigmentation with prolonged use (related to melanocortin activity).
3. Rare:
   • Allergic reactions, including injection site irritation or swelling.

Precautions

• Cardiovascular Conditions:
  • Avoid use in individuals with uncontrolled high blood pressure or cardiovascular disorders, as PT-141 may cause mild increases in blood pressure.
• Pregnancy and Lactation:
  • Not recommended for use during pregnancy or breastfeeding.
• Alcohol:
  • Combining PT-141 with alcohol may increase dizziness and fatigue.

Legal Status

• FDA Approval:
  • PT-141 (Bremelanotide) is FDA-approved under the name Vyleesi for treating hypoactive sexual desire disorder (HSDD) in premenopausal women.
• Research Use:
  • Research-grade PT-141 (like Apoxar 10mg) is sold for experimental purposes and may not meet pharmaceutical standards.

Storage

• Before Reconstitution:
  • Store the lyophilized powder in a cool, dry place away from sunlight.
• After Reconstitution:
  • Store in the refrigerator (2–8°C) and use within 30–60 days, depending on the diluent used.

Comparison to Other Sexual Function Enhancers

• PT-141 vs PDE-5 Inhibitors:
  • PT-141 directly enhances libido and arousal, while PDE-5 inhibitors improve blood flow to the genitals.
  • PT-141 is suitable for psychological or neurological sexual dysfunction, while PDE-5 inhibitors are better for physical causes like poor circulation.

Sample Protocol (Example Use Case)

• Reconstitution: Mix 10 mg of PT-141 with 1 mL of bacteriostatic water to achieve 10 mg/mL concentration.
• Dosage: Inject 0.1–0.2 mL (1–2 mg) subcutaneously 30–60 minutes before activity.
• Cycle: Use as needed, no more than a few times weekly to avoid desensitization.

It is sold under brand names like Vyleesi and is also available in research-grade forms like Apoxar PT-141 10mg. PT-141 works by targeting melanocortin receptors in the brain, which influence sexual arousal and desire.

Mechanism of Action

• Melanocortin Receptor Agonist:
  • PT-141 binds to MC3R and MC4R (melanocortin receptors) in the central nervous system, bypassing hormonal pathways to directly stimulate sexual arousal.
  • Unlike PDE-5 inhibitors (e.g., Viagra), PT-141 does not act on blood flow but on the neurological pathways that trigger sexual desire.

PT-141 (Libido/Sex drive) 10mg – Apoxar Key Benefits

1. Improved Libido:
   • Increases sexual arousal in both men and women.
   • Effective for hypoactive sexual desire disorder (HSDD) in premenopausal women.
2. Erectile Dysfunction (ED) Treatment:
   • Helps men achieve and maintain erections, especially those with ED caused by psychological factors.
3. Enhanced Sexual Pleasure:
   • Many users report heightened sensitivity and overall sexual satisfaction.
4. Alternative to PDE-5 Inhibitors:
   • Ideal for individuals who cannot use drugs like Sildenafil (Viagra) or Tadalafil (Cialis).

Dosage and Administration

• Standard Dosage:
  • 1–2 mg subcutaneously (SC) injected about 30–60 minutes before sexual activity.
  • Dosage can be adjusted based on individual tolerance and effectiveness, with a maximum of 2 mg per day.
• Reconstitution:
  • If provided as a lyophilized powder (e.g., Apoxar PT-141 10mg), reconstitute with bacteriostatic water (typically 1–2 mL) and store in a refrigerator.

Effects Timeline

• Onset: Effects are typically felt within 30–60 minutes of administration.
• Peak: Sexual arousal peaks around 2–4 hours after injection.
• Duration: Effects can last up to 8–12 hours, with residual benefits for up to 24 hours.

Side Effects

1. Common:
   • Nausea (most reported side effect, dose-dependent).
   • Flushing or warmth in the face.
   • Mild headache.
   • Temporary fatigue or dizziness.
2. Less Common:
   • Increased blood pressure (monitor in individuals with hypertension).
   • Darkened skin pigmentation with prolonged use (related to melanocortin activity).
3. Rare:
   • Allergic reactions, including injection site irritation or swelling.

Precautions

• Cardiovascular Conditions:
  • Avoid use in individuals with uncontrolled high blood pressure or cardiovascular disorders, as PT-141 may cause mild increases in blood pressure.
• Pregnancy and Lactation:
  • Not recommended for use during pregnancy or breastfeeding.
• Alcohol:
  • Combining PT-141 with alcohol may increase dizziness and fatigue.

Legal Status

• FDA Approval:
  • PT-141 (Bremelanotide) is FDA-approved under the name Vyleesi for treating hypoactive sexual desire disorder (HSDD) in premenopausal women.
• Research Use:
  • Research-grade PT-141 (like Apoxar 10mg) is sold for experimental purposes and may not meet pharmaceutical standards.

Storage

• Before Reconstitution:
  • Store the lyophilized powder in a cool, dry place away from sunlight.
• After Reconstitution:
  • Store in the refrigerator (2–8°C) and use within 30–60 days, depending on the diluent used.

Comparison to Other Sexual Function Enhancers

• PT-141 vs PDE-5 Inhibitors:
  • PT-141 directly enhances libido and arousal, while PDE-5 inhibitors improve blood flow to the genitals.
  • PT-141 is suitable for psychological or neurological sexual dysfunction, while PDE-5 inhibitors are better for physical causes like poor circulation.

Sample Protocol (Example Use Case)

• Reconstitution: Mix 10 mg of PT-141 with 1 mL of bacteriostatic water to achieve 10 mg/mL concentration.
• Dosage: Inject 0.1–0.2 mL (1–2 mg) subcutaneously 30–60 minutes before activity.
• Cycle: Use as needed, no more than a few times weekly to avoid desensitization.

PT-141 (Libido/Sex drive) 10mg – Apoxar