S-23

S-23 is one of the most potent Selective Androgen Receptor Modulators (SARMs) developed for its strong anabolic effects. It is known for its ability to promote lean muscle growth, strength, and fat loss. However, it is also highly suppressive of natural testosterone production, more so than other SARMs, making it closer in profile to traditional anabolic steroids.

Overview of S-23

• Developed By: Initially studied as a potential male contraceptive due to its suppressive effect on spermatogenesis.
• Mechanism: Binds selectively to androgen receptors in muscle and bone, stimulating anabolic activity while minimizing androgenic effects in other tissues.
• Potency: Considered one of the strongest SARMs, often compared to anabolic steroids in its effects.

Potential Benefits

1. Lean Muscle Mass Growth:
   • Promotes significant increases in muscle size and strength.
2. Fat Loss:
   • Enhances fat oxidation, making it a popular choice for cutting cycles.
3. Muscle Hardness:
   • Provides a dry, vascular appearance, often compared to compounds like Winstrol.
4. Strength Gains:
   • Users report substantial improvements in strength during lifts and physical performance.
5. Bone Density:
   • May improve bone mineral density, reducing the risk of fractures.

Dosage

• Typical Dose: 10–30 mg/day.
• Half-Life: ~12 hours (often split into two doses for consistent blood levels).
• Cycle Length: 6–8 weeks.

Side Effects

S-23 has a more pronounced side effect profile compared to other SARMs. These include:

1. Testosterone Suppression:
   • S-23 is highly suppressive and will likely shut down natural testosterone production. Post-cycle therapy (PCT) is essential.
2. Aggression and Mood Changes:
   • Users report increased aggression, similar to some anabolic steroids.
3. Hair Loss:
   • May accelerate hair loss in individuals predisposed to male pattern baldness.
4. Lipid Profile Changes:
   • Can negatively affect cholesterol levels.
5. Liver Stress:
   • While not as hepatotoxic as oral steroids, some liver stress has been reported.
6. Possible Fertility Effects:
   • As it was initially studied for contraception, it may reduce sperm count temporarily.

Cycle Recommendations

1. Dosage Protocol:
   • Start with a lower dose (e.g., 10 mg/day) to assess tolerance.
   • Gradually increase if no adverse effects are noted.
2. Stacking:
   • Often stacked with milder SARMs like MK-2866 (Ostarine) or GW-501516 (Cardarine) for recomposition or cutting cycles.
3. Support Supplements:
   • Use liver support (e.g., NAC or milk thistle).
   • Include omega-3s or red yeast rice for cholesterol support.

Post-Cycle Therapy (PCT)

Given the strong suppressive nature of S-23, a robust PCT is crucial:

• Compounds: Clomid (Clomiphene Citrate) or Nolvadex (Tamoxifen Citrate).
• Duration: 4–6 weeks.
• Additional Support: Natural testosterone boosters may be used alongside pharmaceutical PCT.

Legal and Ethical Considerations

• Research Status: S-23 is not approved for human use and is classified as a research chemical.
• Banned Substance: Prohibited by WADA and other sports organizations.
• Safety: Long-term effects are not well-studied, and use outside of research settings carries risks.